The Native Methylation Detection pipeline enables researchers to uncover epigenetic modifications in DNA samples without the need for specific treatments. Leveraging the accuracy of long HiFi reads, the pipeline facilitates the detection of SNVs, indels, structural variations, and genome-wide methylation patterns in a single sequencing run. These methylation patterns can be linked to biological functions or gene activity.

Microbiome Epigenetics Study: Measure and assemble the epigenome of microbiota organisms, identifying and characterizing motifs for 4mC and 6mA.
Eukaryotic Epigenetics Study: Investigate and uncover 5mC methylation events at CpG sites during whole genome assembly, without prior treatments (e.g., bisulfite), which may be harmful to the genome sample.

Standard protocol: To view DNA samples specifications, sequencing recommendation and samples shipping guidelines, please download the corresponding SP-Doc.

SP-Doc / Native Methylation Detection

Fasteris | Epigenetics pipelines for modified DNA.